MT-CO1
MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
Overview
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.74, genetic literature 0.30).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
- 1 · What it is
MT-CO1 (Cytochrome c oxidase subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms and Colorectal cancer.
- 2 · What goes wrong in cancer
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
- 3 · How drugs use it
No product in this corpus aims at MT-CO1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7419 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P00395 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198804 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: colorectal cancer 0.50, myelodysplastic syndrome 0.64 (GraphQL API, CC0))
Biology
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A centre (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear centre (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. Location: Mitochondrion inner membrane (UniProt). Locus mitochondria (HGNC).
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.64 with myelodysplastic syndrome (MONDO_0018881)
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MT-CO1" OR ABSTRACT:"MT-CO1" OR TITLE:"mitochondrially encoded cytochrome c oxidase I" OR ABSTRACT:"mitochondrially encoded cytochrome c oxidase I" OR TITLE:"Cytochrome c oxidase subunit 1" OR ABSTRACT:"Cytochrome c oxidase subunit 1" OR TITLE:"COX1" OR ABSTRACT:"COX1" OR TITLE:"MTCO1" OR ABSTRACT:"MTCO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MT-CO1, not a curated reading list.
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