SAMD9
SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
Overview
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
- 1 · What it is
SAMD9 (Sterile alpha motif domain-containing protein 9) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms.
- 2 · What goes wrong in cancer
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules.
- 3 · How drugs use it
No product in this corpus aims at SAMD9 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1348 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5K651 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000205413 (per-cancer scores at or above 0.5: myelodysplastic syndrome 0.66 (GraphQL API, CC0))
Biology
Double-stranded nucleic acid binding that acts as an antiviral factor by playing an essential role in the formation of cytoplasmic antiviral granules. May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF signalling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. Location: Cytoplasm (UniProt). Locus 7q21.2 (HGNC).
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.66 with myelodysplastic syndrome (MONDO_0018881)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SAMD9" OR ABSTRACT:"SAMD9" OR TITLE:"sterile alpha motif domain containing 9" OR ABSTRACT:"sterile alpha motif domain containing 9" OR TITLE:"Sterile alpha motif domain-containing protein 9" OR ABSTRACT:"Sterile alpha motif domain-containing protein 9" OR TITLE:"KIAA2004" OR ABSTRACT:"KIAA2004" OR TITLE:"FLJ20073" OR ABSTRACT:"FLJ20073" OR TITLE:"C7orf5" OR ABSTRACT:"C7orf5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SAMD9, not a curated reading list.
Similar pages
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