MYCL
MYCL (MYCL proto-oncogene, bHLH transcription factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer and Melanoma.
Overview
UniProt has no function text for P12524; HGNC names it "MYCL proto-oncogene, bHLH transcription factor".
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming JQ1 and I-BET151. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.35, genetic association 0.00, somatic mutation 0.96).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYCL (MYCL proto-oncogene, bHLH transcription factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer and Melanoma.
- 1 · What it is
MYCL (MYCL proto-oncogene, bHLH transcription factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer and Melanoma.
- 2 · What goes wrong in cancer
UniProt has no function text for P12524; HGNC names it "MYCL proto-oncogene, bHLH transcription factor". Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at MYCL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7555 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12524 (protein name, function text, keywords and locations (REST API)); CIViC gene MYCL (1 evidence items, 0 assertions, 1 variants; diseases: Multiple Myeloma (GraphQL API, CC0)); Open Targets ENSG00000116990 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.56 (GraphQL API, CC0))
Biology
UniProt has no function text for P12524; HGNC names it "MYCL proto-oncogene, bHLH transcription factor". Location: Nucleus (UniProt). Locus 1p34.2 (HGNC).
- Multiple myeloma: CIViC evidence names this disease
- Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MYCL" OR ABSTRACT:"MYCL" OR TITLE:"MYCL proto-oncogene, bHLH transcription factor" OR ABSTRACT:"MYCL proto-oncogene, bHLH transcription factor" OR TITLE:"bHLHe38" OR ABSTRACT:"bHLHe38" OR TITLE:"MYCL1" OR ABSTRACT:"MYCL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYCL, not a curated reading list.