NAB2
NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.54, genetic association 0.00, somatic mutation 0.89).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
NAB2 (NGFI-A-binding protein 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
- 3 · How drugs use it
No product in this corpus aims at NAB2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7627 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15742 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166886 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. Location: Nucleus (UniProt). Locus 12q13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NAB2" OR ABSTRACT:"NAB2" OR TITLE:"NGFI-A binding protein 2" OR ABSTRACT:"NGFI-A binding protein 2" OR TITLE:"NGFI-A-binding protein 2" OR ABSTRACT:"NGFI-A-binding protein 2" OR TITLE:"MADER" OR ABSTRACT:"MADER") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NAB2, not a curated reading list.