NAF1
NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.43, genetic literature 0.76).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
NAF1 (H/ACA ribonucleoprotein complex non-core subunit NAF1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.
- 3 · How drugs use it
No product in this corpus aims at NAF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25126 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96HR8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145414 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4. Location: Cytoplasm; Nucleus (UniProt). Locus 4q32.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NAF1" OR ABSTRACT:"NAF1" OR TITLE:"nuclear assembly factor 1 ribonucleoprotein" OR ABSTRACT:"nuclear assembly factor 1 ribonucleoprotein" OR TITLE:"H/ACA ribonucleoprotein complex non-core subunit NAF1" OR ABSTRACT:"H/ACA ribonucleoprotein complex non-core subunit NAF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NAF1, not a curated reading list.