NEDD9
NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Overview
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 1 · What it is
NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
- 2 · What goes wrong in cancer
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration.
- 3 · How drugs use it
No product in this corpus aims at NEDD9 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7733 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14511 (protein name, function text, keywords and locations (REST API)); CIViC gene NEDD9 (1 evidence items, 0 assertions, 1 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Biology
Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form. Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs. Plays a role in the organisation of T-cell F-actin cortical cytoskeleton and the centralisation of T-cell receptor microclusters at the immunological synapse. Location: Cytoplasm, cell cortex; Nucleus; Golgi apparatus; Cell projection, lamellipodium (UniProt). Locus 6p24.2 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NEDD9" OR ABSTRACT:"NEDD9" OR TITLE:"neural precursor cell expressed, developmentally down-regulated 9" OR ABSTRACT:"neural precursor cell expressed, developmentally down-regulated 9" OR TITLE:"Enhancer of filamentation 1" OR ABSTRACT:"Enhancer of filamentation 1" OR TITLE:"HEF1" OR ABSTRACT:"HEF1" OR TITLE:"CAS-L" OR ABSTRACT:"CAS-L" OR TITLE:"CASS2" OR ABSTRACT:"CASS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NEDD9, not a curated reading list.