NPTXR
NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
Overview
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin and Fluorouracil.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
- 1 · What it is
NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
- 2 · What goes wrong in cancer
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at NPTXR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:7954 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95502 (protein name, function text, keywords and locations (REST API)); CIViC gene NPTXR (1 evidence items, 0 assertions, 1 variants; diseases: Stomach Carcinoma (GraphQL API, CC0))
Biology
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).
- Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NPTXR" OR ABSTRACT:"NPTXR" OR TITLE:"neuronal pentraxin receptor" OR ABSTRACT:"neuronal pentraxin receptor" OR TITLE:"Neuronal pentraxin receptor" OR ABSTRACT:"Neuronal pentraxin receptor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NPTXR, not a curated reading list.