NR2F2
NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro).
- 3 · How drugs use it
No product in this corpus aims at NR2F2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7976 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P24468 (protein name, function text, keywords and locations (REST API)); CIViC gene NR2F2 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Biology
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Location: Nucleus (UniProt). Locus 15q26.2 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NR2F2" OR ABSTRACT:"NR2F2" OR TITLE:"nuclear receptor subfamily 2 group F member 2" OR ABSTRACT:"nuclear receptor subfamily 2 group F member 2" OR TITLE:"COUP transcription factor 2" OR ABSTRACT:"COUP transcription factor 2" OR TITLE:"COUP-TFII" OR ABSTRACT:"COUP-TFII" OR TITLE:"COUPTFB" OR ABSTRACT:"COUPTFB" OR TITLE:"SVP40" OR ABSTRACT:"SVP40") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NR2F2, not a curated reading list.