NUTM2B
NUTM2B (NUT family member 2B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
Overview
UniProt has no function text for A6NNL0; HGNC names it "NUT family member 2B".
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.70, genetic association 0.00, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NUTM2B (NUT family member 2B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
- 1 · What it is
NUTM2B (NUT family member 2B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas.
- 2 · What goes wrong in cancer
UniProt has no function text for A6NNL0; HGNC names it "NUT family member 2B". Locus 10q22.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at NUTM2B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:23445 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NNL0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000188199 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: sarcoma 0.58 (GraphQL API, CC0))
Biology
UniProt has no function text for A6NNL0; HGNC names it "NUT family member 2B". Locus 10q22.3 (HGNC).
- Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NUTM2B" OR ABSTRACT:"NUTM2B" OR TITLE:"NUT family member 2B" OR ABSTRACT:"NUT family member 2B" OR TITLE:"bA119F19.1" OR ABSTRACT:"bA119F19.1" OR TITLE:"FAM22B" OR ABSTRACT:"FAM22B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUTM2B, not a curated reading list.