OGG1
OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.89, literature 0.98, genetic association 0.01, somatic mutation 0.55, animal model 0.74).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA.
- 3 · How drugs use it
No product in this corpus aims at OGG1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:8125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15527 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114026 (association with cancer (MONDO_0004992) 0.66; (GraphQL API, CC0))
Biology
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Location: Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus (UniProt). Locus 3p25.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"OGG1" OR ABSTRACT:"OGG1" OR TITLE:"8-oxoguanine DNA glycosylase" OR ABSTRACT:"8-oxoguanine DNA glycosylase" OR TITLE:"N-glycosylase/DNA lyase" OR ABSTRACT:"N-glycosylase/DNA lyase" OR TITLE:"HOGG1" OR ABSTRACT:"HOGG1" OR TITLE:"OGH1" OR ABSTRACT:"OGH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OGG1, not a curated reading list.