ORC1
ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Overview
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
- 1 · What it is
ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
- 2 · What goes wrong in cancer
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.
- 3 · How drugs use it
No product in this corpus aims at ORC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:8487 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13415 (protein name, function text, keywords and locations (REST API)); CIViC gene ORC1 (1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0))
Biology
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Location: Nucleus (UniProt). Locus 1p32.3 (HGNC).
- Triple-negative breast cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ORC1" OR ABSTRACT:"ORC1" OR TITLE:"origin recognition complex subunit 1" OR ABSTRACT:"origin recognition complex subunit 1" OR TITLE:"Origin recognition complex subunit 1" OR ABSTRACT:"Origin recognition complex subunit 1" OR TITLE:"HSORC1" OR ABSTRACT:"HSORC1" OR TITLE:"PARC1" OR ABSTRACT:"PARC1" OR TITLE:"ORC1L" OR ABSTRACT:"ORC1L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ORC1, not a curated reading list.