Prostatic acid phosphatase (ACP3, PAP)
Prostatic acid phosphatase is an enzyme made almost only by the prostate; the cell vaccine sipuleucel-T trains a patient's immune cells against it.
Overview
Prostatic acid phosphatase (PAP, gene ACP3) is secreted by prostate epithelium and was the prostate cancer blood marker before PSA. Because it is nearly prostate-specific, it serves as the antigen for sipuleucel-T: the patient's antigen-presenting cells are loaded with a PAP-GM-CSF fusion protein and re-infused to raise an anti-PAP immune response in metastatic castration-resistant prostate cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · Prostatic acid phosphatase is an enzyme made almost only by the prostate; the cell vaccine sipuleucel-T trains a patient's immune cells against it.
- 1 · What it is
Prostatic acid phosphatase is an enzyme made almost only by the prostate; the cell vaccine sipuleucel-T trains a patient's immune cells against it.
- 2 · What goes wrong in cancer
A prostate-restricted phosphatase found in secreted and transmembrane forms; expression persists in most prostate cancers.
- 3 · How drugs use it
No product in this corpus aims at Prostatic acid phosphatase (ACP3, PAP) yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Biology
A prostate-restricted phosphatase found in secreted and transmembrane forms; expression persists in most prostate cancers.
- Prostate epithelium and prostate cancer (most cases)
- Low in other tissues
Latest papers
topQuery for this target: (TITLE:"Prostatic acid phosphatase" OR ABSTRACT:"Prostatic acid phosphatase" OR TITLE:"ACP3, PAP" OR ABSTRACT:"ACP3, PAP" OR TITLE:"ACP3" OR ABSTRACT:"ACP3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Prostatic acid phosphatase (ACP3, PAP), not a curated reading list.
Similar pages
not linked directly; found by shared links- CompanyDendreon
Shares Sipuleucel-T, Prostate cancer.