PARP3
PARP3 (Protein mono-ADP-ribosyltransferase PARP3) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer and Prostate cancer.
Overview
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.00, clinical 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PARP3 (Protein mono-ADP-ribosyltransferase PARP3) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer and Prostate cancer.
- 1 · What it is
PARP3 (Protein mono-ADP-ribosyltransferase PARP3) is an enzyme. The public catalogues list it as a drug target and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer and Prostate cancer.
- 2 · What goes wrong in cancer
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins.
- 3 · How drugs use it
No product in this corpus aims at PARP3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:273 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6F1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000041880 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: prostate cancer 0.51, ovarian cancer 0.59 (GraphQL API, CC0))
Biology
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. Involved in single-strand break repair by catalysing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 3p21.2 (HGNC).
- Ovarian cancer: Open Targets association 0.59 with ovarian cancer (MONDO_0008170)
- Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.98; UniProt keyword "DNA repair". Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PARP3" OR ABSTRACT:"PARP3" OR TITLE:"poly ADP-ribose polymerase family member 3" OR ABSTRACT:"poly ADP-ribose polymerase family member 3" OR TITLE:"Protein mono-ADP-ribosyltransferase PARP3" OR ABSTRACT:"Protein mono-ADP-ribosyltransferase PARP3" OR TITLE:"ADPRT3" OR ABSTRACT:"ADPRT3" OR TITLE:"IRT1" OR ABSTRACT:"IRT1" OR TITLE:"hPARP-3" OR ABSTRACT:"hPARP-3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PARP3, not a curated reading list.