PCNX2
PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.63, animal model 0.52, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
PCNX2 (Pecanex-like protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PCNX2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:8736 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NKB5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135749 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Location: Membrane (UniProt). Locus 1q42.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PCNX2" OR ABSTRACT:"PCNX2" OR TITLE:"pecanex 2" OR ABSTRACT:"pecanex 2" OR TITLE:"Pecanex-like protein 2" OR ABSTRACT:"Pecanex-like protein 2" OR TITLE:"KIAA0435" OR ABSTRACT:"KIAA0435" OR TITLE:"FLJ11383" OR ABSTRACT:"FLJ11383" OR TITLE:"PCNXL2" OR ABSTRACT:"PCNXL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PCNX2, not a curated reading list.