PDGFRL
PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like".
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.30, genetic association 0.47, somatic mutation 0.55, animal model 0.43).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
PDGFRL (Platelet-derived growth factor receptor-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like". Location: Secreted (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PDGFRL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:8805 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15198 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104213 (association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: colorectal cancer 0.50 (GraphQL API, CC0))
Biology
UniProt has no function text for Q15198; HGNC names it "platelet derived growth factor receptor like". Location: Secreted (UniProt). Locus 8p22 (HGNC).
- Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PDGFRL" OR ABSTRACT:"PDGFRL" OR TITLE:"platelet derived growth factor receptor like" OR ABSTRACT:"platelet derived growth factor receptor like" OR TITLE:"Platelet-derived growth factor receptor-like protein" OR ABSTRACT:"Platelet-derived growth factor receptor-like protein" OR TITLE:"PRLTS" OR ABSTRACT:"PRLTS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDGFRL, not a curated reading list.