PDLIM5
PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1.
Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.64).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
PDLIM5 (PDZ and LIM domain protein 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion.
- 3 · How drugs use it
No product in this corpus aims at PDLIM5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17468 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96HC4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163110 (association with cancer (MONDO_0004992) 0.50; per-cancer scores at or above 0.5: prostate cancer 0.50 (GraphQL API, CC0))
Biology
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Location: Postsynaptic density; Presynapse; Postsynapse; Cytoplasm, cytosol (UniProt). Locus 4q22.3 (HGNC).
- Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PDLIM5" OR ABSTRACT:"PDLIM5" OR TITLE:"PDZ and LIM domain 5" OR ABSTRACT:"PDZ and LIM domain 5" OR TITLE:"PDZ and LIM domain protein 5" OR ABSTRACT:"PDZ and LIM domain protein 5" OR TITLE:"Enh" OR ABSTRACT:"Enh") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDLIM5, not a curated reading list.