PMS1
PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Probably involved in the repair of mismatches in DNA.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.38, genetic association 0.76, somatic mutation 0.50, genetic literature 0.01).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
PMS1 (PMS1 protein homolog 1) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PMS1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9121 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P54277 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000064933 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.51 (GraphQL API, CC0))
Biology
Probably involved in the repair of mismatches in DNA. Location: Nucleus (UniProt). Locus 2q32.2 (HGNC).
- Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PMS1" OR ABSTRACT:"PMS1" OR TITLE:"PMS1 homolog 1, mismatch repair system component" OR ABSTRACT:"PMS1 homolog 1, mismatch repair system component" OR TITLE:"PMS1 protein homolog 1" OR ABSTRACT:"PMS1 protein homolog 1" OR TITLE:"MLH2" OR ABSTRACT:"MLH2" OR TITLE:"PMSL1" OR ABSTRACT:"PMSL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PMS1, not a curated reading list.