POU2AF1
POU2AF1 (POU domain class 2-associating factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Lung cancer, Skin cancer and 1 more.
Overview
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognises the POU domains of POU2F1/OCT1 and POU2F2/OCT2.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.00, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · POU2AF1 (POU domain class 2-associating factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Lung cancer, Skin cancer and 1 more.
- 1 · What it is
POU2AF1 (POU domain class 2-associating factor 1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Lung cancer, Skin cancer and 1 more.
- 2 · What goes wrong in cancer
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2.
- 3 · How drugs use it
No product in this corpus aims at POU2AF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:9211 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16633 (protein name, function text, keywords and locations (REST API)); CIViC gene POU2AF1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000110777 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: non-Hodgkin lymphoma 0.54, skin cancer 0.50, lung cancer 0.51 (GraphQL API, CC0))
Biology
Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognises the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centres. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator. Location: Nucleus (UniProt). Locus 11q23.1 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)
- Diffuse large B-cell lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"POU2AF1" OR ABSTRACT:"POU2AF1" OR TITLE:"POU class 2 homeobox associating factor 1" OR ABSTRACT:"POU class 2 homeobox associating factor 1" OR TITLE:"POU domain class 2-associating factor 1" OR ABSTRACT:"POU domain class 2-associating factor 1" OR TITLE:"OBF1" OR ABSTRACT:"OBF1" OR TITLE:"BOB1" OR ABSTRACT:"BOB1" OR TITLE:"OCA-B" OR ABSTRACT:"OCA-B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POU2AF1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTNFRSF14
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.
- TargetBCL6
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.
- TargetCIITA
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.
- TargetEBF1
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.
- TargetP2RY8
Shares Lung cancer (all types), Non-Hodgkin lymphoma (all types), CIViC, Diffuse large B-cell lymphoma.
- TargetRMI2
Shares Lung cancer (all types), Non-Hodgkin lymphoma (all types), Diffuse large B-cell lymphoma, Open Targets Platform.
- TargetPAX5
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.
- TargetTBL1XR1
Shares Lung cancer (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), CIViC.