POU5F1B
POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
Overview
Shows weak transcriptional activator activity.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.85).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
- 1 · What it is
POU5F1B (POU domain, class 5, transcription factor 1B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer and Colorectal cancer.
- 2 · What goes wrong in cancer
Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at POU5F1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:9223 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06416 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000212993 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.56, prostate cancer 0.64 (GraphQL API, CC0))
Biology
Shows weak transcriptional activator activity. Location: Nucleus; Cytoplasm (UniProt). Locus 8q24.21 (HGNC).
- Prostate cancer: Open Targets association 0.64 with prostate cancer (MONDO_0008315)
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"POU5F1B" OR ABSTRACT:"POU5F1B" OR TITLE:"POU class 5 homeobox 1B" OR ABSTRACT:"POU class 5 homeobox 1B" OR TITLE:"POU domain, class 5, transcription factor 1B" OR ABSTRACT:"POU domain, class 5, transcription factor 1B" OR TITLE:"OTF3C" OR ABSTRACT:"OTF3C" OR TITLE:"OTF3P1" OR ABSTRACT:"OTF3P1" OR TITLE:"POU5F1P1" OR ABSTRACT:"POU5F1P1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about POU5F1B, not a curated reading list.