PPP1R14A
PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.74).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
- 3 · How drugs use it
No product in this corpus aims at PPP1R14A yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:14871 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96A00 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167641 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: prostate cancer 0.56 (GraphQL API, CC0))
Biology
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Location: Cytoplasm (UniProt). Locus 19q13.1 (HGNC).
- Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPP1R14A" OR ABSTRACT:"PPP1R14A" OR TITLE:"protein phosphatase 1 regulatory inhibitor subunit 14A" OR ABSTRACT:"protein phosphatase 1 regulatory inhibitor subunit 14A" OR TITLE:"Protein phosphatase 1 regulatory subunit 14A" OR ABSTRACT:"Protein phosphatase 1 regulatory subunit 14A" OR TITLE:"CPI-17" OR ABSTRACT:"CPI-17" OR TITLE:"PPP1INL" OR ABSTRACT:"PPP1INL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP1R14A, not a curated reading list.