PPP2R1B
PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.89, genetic association 0.51, somatic mutation 0.55).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
PPP2R1B (Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at PPP2R1B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9303 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P30154 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137713 (association with cancer (MONDO_0004992) 0.68; (GraphQL API, CC0))
Biology
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Locus 11q23.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPP2R1B" OR ABSTRACT:"PPP2R1B" OR TITLE:"protein phosphatase 2 scaffold subunit Abeta" OR ABSTRACT:"protein phosphatase 2 scaffold subunit Abeta" OR TITLE:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform" OR TITLE:"PR65B" OR ABSTRACT:"PR65B" OR TITLE:"PP2A-Abeta" OR ABSTRACT:"PP2A-Abeta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R1B, not a curated reading list.