PPP2R5B
PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.27, affected pathway 0.89, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
PPP2R5B (Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation.
- 3 · How drugs use it
No product in this corpus aims at PPP2R5B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9310 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15173 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000068971 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Biology
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localisation, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. Location: Cytoplasm (UniProt). Locus 11q13.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PPP2R5B" OR ABSTRACT:"PPP2R5B" OR TITLE:"protein phosphatase 2 regulatory subunit B'beta" OR ABSTRACT:"protein phosphatase 2 regulatory subunit B'beta" OR TITLE:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform" OR ABSTRACT:"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform" OR TITLE:"FLJ35411" OR ABSTRACT:"FLJ35411" OR TITLE:"B56B" OR ABSTRACT:"B56B" OR TITLE:"PR61B" OR ABSTRACT:"PR61B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP2R5B, not a curated reading list.