PSCA
PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
Overview
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.64, genetic association 0.69, clinical 0.17).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
- 1 · What it is
PSCA (Prostate stem cell antigen) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.
- 2 · What goes wrong in cancer
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
- 3 · How drugs use it
No product in this corpus aims at PSCA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9500 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43653 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000167653 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: gastric cancer 0.53 (GraphQL API, CC0))
Biology
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signalling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. Location: Cell membrane (UniProt). Locus 8q24.3 (HGNC).
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.53 with gastric cancer (MONDO_0001056)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.17. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PSCA" OR ABSTRACT:"PSCA" OR TITLE:"prostate stem cell antigen" OR ABSTRACT:"prostate stem cell antigen" OR TITLE:"Prostate stem cell antigen" OR ABSTRACT:"Prostate stem cell antigen" OR TITLE:"lncPSCA" OR ABSTRACT:"lncPSCA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PSCA, not a curated reading list.