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BPX-601 is an experimental autologous CAR-T cell therapy from Bellicum Pharmaceuticals, in phase 1 trials for metastatic castration-resistant prostate cancer.
BPX-601 is an autologous CAR-T cell therapy (GoCAR platform) from Bellicum Pharmaceuticals, with Regeneron Pharmaceuticals as acquirer. An autologous GoCAR-T product containing Bellicum's inducible MyD88/CD40 (iMC) activation switch, designed to treat solid tumours expressing prostate stem cell antigen (PSCA). Its furthest stage is phase 1, for metastatic castration-resistant prostate cancer. ClinicalTrials.gov registers it in 2 studies linked below. Bellicum discontinued its trial in March 2023, but ClinicalTrials.gov now lists Regeneron Pharmaceuticals as sponsor of a new phase 1 (NCT07543055, recruiting, start 8 Sept 2026) and of the earlier NCT02744287 (terminated). Whether it works in people has not been established unless a trial below reports it.
An autologous GoCAR-T product containing Bellicum's inducible MyD88/CD40 (iMC) activation switch, designed to treat solid tumours expressing prostate stem cell antigen (PSCA). Connects to PSCA.
1.BPX-601 slips into a pocket on PSCA.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"BPX-601" OR ABSTRACT:"BPX-601") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BPX-601, not a curated reading list.
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