PTP4A3
PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Overview
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 1 · What it is
PTP4A3 (Protein tyrosine phosphatase type IVA 3) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
- 3 · How drugs use it
No product in this corpus aims at PTP4A3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:9636 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75365 (protein name, function text, keywords and locations (REST API)); CIViC gene PTP4A3 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Biology
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilisation in response to angiotensin II. Location: Cell membrane; Early endosome (UniProt). Locus 8q24.3 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PTP4A3" OR ABSTRACT:"PTP4A3" OR TITLE:"protein tyrosine phosphatase 4A3" OR ABSTRACT:"protein tyrosine phosphatase 4A3" OR TITLE:"Protein tyrosine phosphatase type IVA 3" OR ABSTRACT:"Protein tyrosine phosphatase type IVA 3" OR TITLE:"PRL-3" OR ABSTRACT:"PRL-3" OR TITLE:"PRL-R" OR ABSTRACT:"PRL-R" OR TITLE:"PRL3" OR ABSTRACT:"PRL3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTP4A3, not a curated reading list.