PTPN12
PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
Overview
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Crizotinib and Sunitinib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
- 1 · What it is
PTPN12 (Tyrosine-protein phosphatase non-receptor type 12) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.
- 2 · What goes wrong in cancer
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2.
- 3 · How drugs use it
No product in this corpus aims at PTPN12 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:9645 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q05209 (protein name, function text, keywords and locations (REST API)); CIViC gene PTPN12 (1 evidence items, 0 assertions, 1 variants; diseases: Triple-negative Breast Cancer (GraphQL API, CC0))
Biology
Dephosphorylates a range of proteins, and thereby regulates cellular signalling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signalling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. Location: Cytoplasm; Cell junction, focal adhesion; Cell projection, podosome (UniProt). Locus 7q11.23 (HGNC).
- Triple-negative breast cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PTPN12" OR ABSTRACT:"PTPN12" OR TITLE:"protein tyrosine phosphatase non-receptor type 12" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 12" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 12" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 12" OR TITLE:"PTPG1" OR ABSTRACT:"PTPG1" OR TITLE:"PTP-PEST" OR ABSTRACT:"PTP-PEST") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN12, not a curated reading list.