RAD51D
RAD51D (DNA repair protein RAD51 homolog 4) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Breast cancer, Gastric & gastro-oesophageal junction cancer and 3 more.
Overview
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Olaparib. Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.88, affected pathway 0.87, literature 0.86, genetic association 0.87, somatic mutation 0.86).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RAD51D (DNA repair protein RAD51 homolog 4) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Breast cancer, Gastric & gastro-oesophageal junction cancer and 3 more.
- 1 · What it is
RAD51D (DNA repair protein RAD51 homolog 4) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer, Breast cancer, Gastric & gastro-oesophageal junction cancer and 3 more.
- 2 · What goes wrong in cancer
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity.
- 3 · How drugs use it
No product in this corpus aims at RAD51D yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:9823 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75771 (protein name, function text, keywords and locations (REST API)); CIViC gene RAD51D (2 evidence items, 0 assertions, 2 variants; diseases: Breast Cancer, Castration-resistant Prostate Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000185379 (association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: colorectal cancer 0.59, gastric cancer 0.64, ovarian cancer 0.80, brain cancer 0.51, breast cancer 0.78 (GraphQL API, CC0))
Biology
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, telomere (UniProt). Locus 17q12 (HGNC).
- Ovarian cancer: Open Targets association 0.80 with ovarian cancer (MONDO_0008170)
- Breast cancer: Open Targets association 0.78 with breast cancer (MONDO_0007254); CIViC evidence names this disease
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.64 with gastric cancer (MONDO_0001056)
- Prostate cancer: CIViC evidence names this disease
- Colorectal cancer: Open Targets association 0.59 with colorectal cancer (MONDO_0005575)
- Brain and spinal cord tumours: Open Targets association 0.51 with brain cancer (MONDO_0001657)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RAD51D" OR ABSTRACT:"RAD51D" OR TITLE:"RAD51 paralog D" OR ABSTRACT:"RAD51 paralog D" OR TITLE:"DNA repair protein RAD51 homolog 4" OR ABSTRACT:"DNA repair protein RAD51 homolog 4" OR TITLE:"R51H3" OR ABSTRACT:"R51H3" OR TITLE:"Trad" OR ABSTRACT:"Trad" OR TITLE:"HsTRAD" OR ABSTRACT:"HsTRAD") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD51D, not a curated reading list.
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