MUTYH
MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
Overview
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.66, affected pathway 0.87, literature 0.85, genetic association 0.81, somatic mutation 0.91).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
- 1 · What it is
MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
- 2 · What goes wrong in cancer
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone.
- 3 · How drugs use it
No product in this corpus aims at MUTYH yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:7527 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UIF7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132781 (association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: colorectal cancer 0.78, gastric cancer 0.72, ovarian cancer 0.57, endometrial cancer 0.51, melanoma 0.51, skin cancer 0.55 (GraphQL API, CC0))
Biology
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Location: Nucleus; Mitochondrion (UniProt). Locus 1p34.1 (HGNC).
- Colorectal cancer: Open Targets association 0.78 with colorectal cancer (MONDO_0005575)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.72 with gastric cancer (MONDO_0001056)
- Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.57 with ovarian cancer (MONDO_0008170)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.52 with lung cancer (MONDO_0008903)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"MUTYH" OR ABSTRACT:"MUTYH" OR TITLE:"mutY DNA glycosylase" OR ABSTRACT:"mutY DNA glycosylase" OR TITLE:"Adenine DNA glycosylase" OR ABSTRACT:"Adenine DNA glycosylase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUTYH, not a curated reading list.
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