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MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Open Targets scores its association with cancer at 0.86 (direct and indirect evidence; datatypes genetic literature 0.66, affected pathway 0.87, literature 0.85, genetic association 0.81, somatic mutation 0.91).
In plain words · MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
MUTYH (Adenine DNA glycosylase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer, Breast cancer and 5 more.
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone.
3 products aim at MUTYH: other agents. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1996. Earliest sequence paper UniProt cites for the protein: Slupska M.M. et al, J. Bacteriol, 1996, "Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage". Source.
Sources: HGNC HGNC:7527 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UIF7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000132781 (association with cancer (MONDO_0004992) 0.86; per-cancer scores at or above 0.5: colorectal cancer 0.78, gastric cancer 0.72, ovarian cancer 0.57, endometrial cancer 0.51, melanoma 0.51, skin cancer 0.55 (GraphQL API, CC0))
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities. Location: Nucleus; Mitochondrion (UniProt). Locus 1p34.1 (HGNC).
A saliva test sold directly to the public that looks for two common changes in the MUTYH gene, which in two copies cause an inherited bowel polyp condition. A negative result does not rule out other MUTYH changes.
Color Health's test of 29 genes linked to inherited breast, ovarian, bowel, stomach, pancreatic, prostate and skin cancer risk.
A blood test of 47 genes, authorised by the US regulator and ordered by a clinician, that finds inherited changes which raise cancer risk or explain a cancer already diagnosed.
Query for this target: (TITLE:"MUTYH" OR ABSTRACT:"MUTYH" OR TITLE:"mutY DNA glycosylase" OR ABSTRACT:"mutY DNA glycosylase" OR TITLE:"Adenine DNA glycosylase" OR ABSTRACT:"Adenine DNA glycosylase") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MUTYH, not a curated reading list.
Shares Brain and spinal cord tumours (all types), Skin cancer (all types), Gastric & gastro-oesophageal junction cancer, Lung cancer (all types).
Shares Color Hereditary Cancer Test, Invitae Common Hereditary Cancers Panel, Endometrial cancer, Skin cancer (all types).
Shares Invitae Common Hereditary Cancers Panel, Endometrial cancer, Skin cancer (all types), Gastric & gastro-oesophageal junction cancer.
Shares Invitae Common Hereditary Cancers Panel, Endometrial cancer, Skin cancer (all types), Gastric & gastro-oesophageal junction cancer.
Shares Brain and spinal cord tumours (all types), Endometrial cancer, Skin cancer (all types), Lung cancer (all types).
Shares Color Hereditary Cancer Test, Invitae Common Hereditary Cancers Panel, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
Shares Color Hereditary Cancer Test, Invitae Common Hereditary Cancers Panel, Endometrial cancer, Skin cancer (all types).
Shares Color Hereditary Cancer Test, Invitae Common Hereditary Cancers Panel, Endometrial cancer, Skin cancer (all types).
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