RAP1A
RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.97, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
RAP1A (Ras-related protein Rap-1A) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes.
- 3 · How drugs use it
No product in this corpus aims at RAP1A yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:9855 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62834 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000116473 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localisation to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signalling and its interaction with PKP3. Location: Cell membrane; Cytoplasm; Cytoplasm, perinuclear region; Cell junction (UniProt). Locus 1p13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RAP1A" OR ABSTRACT:"RAP1A" OR TITLE:"RAP1A, member of RAS oncogene family" OR ABSTRACT:"RAP1A, member of RAS oncogene family" OR TITLE:"Ras-related protein Rap-1A" OR ABSTRACT:"Ras-related protein Rap-1A" OR TITLE:"KREV-1" OR ABSTRACT:"KREV-1" OR TITLE:"SMGP21" OR ABSTRACT:"SMGP21") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAP1A, not a curated reading list.