RHOBTB2
RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.67, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g.
- 3 · How drugs use it
No product in this corpus aims at RHOBTB2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:18756 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BYZ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000008853 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Biology
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RHOBTB2" OR ABSTRACT:"RHOBTB2" OR TITLE:"Rho related BTB domain containing 2" OR ABSTRACT:"Rho related BTB domain containing 2" OR TITLE:"Rho-related BTB domain-containing protein 2" OR ABSTRACT:"Rho-related BTB domain-containing protein 2" OR TITLE:"KIAA0717" OR ABSTRACT:"KIAA0717" OR TITLE:"DBC2" OR ABSTRACT:"DBC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RHOBTB2, not a curated reading list.