SBDS
SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
Overview
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.75, genetic association 0.00, somatic mutation 0.74, genetic literature 0.87).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
- 1 · What it is
SBDS (Ribosome maturation protein SBDS) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Acute myeloid leukaemia.
- 2 · What goes wrong in cancer
Required for the assembly of mature ribosomes and ribosome biogenesis.
- 3 · How drugs use it
No product in this corpus aims at SBDS yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:19440 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y3A5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126524 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.60, myeloproliferative neoplasm 0.60, leukaemia 0.62 (GraphQL API, CC0))
Biology
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Location: Cytoplasm; Nucleus, nucleolus; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 7q11.21 (HGNC).
- Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.60 with myeloproliferative neoplasm (MONDO_0020076)
- Acute myeloid leukaemia: Open Targets association 0.60 with acute myeloid leukaemia (MONDO_0018874)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SBDS" OR ABSTRACT:"SBDS" OR TITLE:"SBDS ribosome maturation factor" OR ABSTRACT:"SBDS ribosome maturation factor" OR TITLE:"Ribosome maturation protein SBDS" OR ABSTRACT:"Ribosome maturation protein SBDS" OR TITLE:"CGI-97" OR ABSTRACT:"CGI-97" OR TITLE:"FLJ10917" OR ABSTRACT:"FLJ10917" OR TITLE:"SDO1" OR ABSTRACT:"SDO1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SBDS, not a curated reading list.
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