SFRP4
SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
Overview
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, animal model 0.54, genetic association 0.14, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
- 1 · What it is
SFRP4 (Secreted frizzled-related protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer, Gastric & gastro-oesophageal junction cancer and Skin cancer.
- 2 · What goes wrong in cancer
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types.
- 3 · How drugs use it
No product in this corpus aims at SFRP4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10778 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6FHJ7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000106483 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: colorectal cancer 0.54, gastric cancer 0.52, skin cancer 0.52 (GraphQL API, CC0))
Biology
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signalling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signalling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Location: Secreted (UniProt). Locus 7p14.1 (HGNC).
- Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SFRP4" OR ABSTRACT:"SFRP4" OR TITLE:"secreted frizzled related protein 4" OR ABSTRACT:"secreted frizzled related protein 4" OR TITLE:"Secreted frizzled-related protein 4" OR ABSTRACT:"Secreted frizzled-related protein 4" OR TITLE:"frpHE" OR ABSTRACT:"frpHE" OR TITLE:"FRP-4" OR ABSTRACT:"FRP-4" OR TITLE:"FRPHE" OR ABSTRACT:"FRPHE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SFRP4, not a curated reading list.