SH3GL1
SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.69, genetic association 0.01, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
SH3GL1 (Endophilin-A2) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles.
- 3 · How drugs use it
No product in this corpus aims at SH3GL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10830 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99961 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141985 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Location: Cytoplasm; Early endosome membrane; Cell projection, podosome (UniProt). Locus 19p13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SH3GL1" OR ABSTRACT:"SH3GL1" OR TITLE:"SH3 domain containing GRB2 like 1, endophilin A2" OR ABSTRACT:"SH3 domain containing GRB2 like 1, endophilin A2" OR TITLE:"Endophilin-A2" OR ABSTRACT:"Endophilin-A2" OR TITLE:"SH3P8" OR ABSTRACT:"SH3P8" OR TITLE:"SH3D2B" OR ABSTRACT:"SH3D2B" OR TITLE:"CNSA1" OR ABSTRACT:"CNSA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SH3GL1, not a curated reading list.