SIDT1
SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SIDT1 (SID1 transmembrane family member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded.
- 3 · How drugs use it
No product in this corpus aims at SIDT1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:25967 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NXL6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000072858 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Location: Membrane (UniProt). Locus 3q13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SIDT1" OR ABSTRACT:"SIDT1" OR TITLE:"SID1 transmembrane family member 1" OR ABSTRACT:"SID1 transmembrane family member 1" OR TITLE:"FLJ20174" OR ABSTRACT:"FLJ20174" OR TITLE:"SID-1" OR ABSTRACT:"SID-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIDT1, not a curated reading list.