SIM2
SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.85, animal model 0.40, genetic association 0.66).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
SIM2 (Single-minded homolog 2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
- 3 · How drugs use it
No product in this corpus aims at SIM2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:10883 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14190 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000159263 (association with cancer (MONDO_0004992) 0.53; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Biology
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development. Location: Nucleus (UniProt). Locus 21q22.13 (HGNC).
- Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SIM2" OR ABSTRACT:"SIM2" OR TITLE:"SIM bHLH transcription factor 2" OR ABSTRACT:"SIM bHLH transcription factor 2" OR TITLE:"Single-minded homolog 2" OR ABSTRACT:"Single-minded homolog 2" OR TITLE:"MGC119447" OR ABSTRACT:"MGC119447" OR TITLE:"bHLHe15" OR ABSTRACT:"bHLHe15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SIM2, not a curated reading list.