SKIL
SKIL (Ski-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Overview
May have regulatory role in cell division or differentiation in response to extracellular signals.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.95, animal model 0.37, genetic association 0.62, somatic mutation 0.23).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SKIL (Ski-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 1 · What it is
SKIL (Ski-like protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
- 2 · What goes wrong in cancer
May have regulatory role in cell division or differentiation in response to extracellular signals. Locus 3q26.2 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at SKIL yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10897 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12757 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136603 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Biology
May have regulatory role in cell division or differentiation in response to extracellular signals. Locus 3q26.2 (HGNC).
- Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SKIL" OR ABSTRACT:"SKIL" OR TITLE:"SKI like proto-oncogene" OR ABSTRACT:"SKI like proto-oncogene" OR TITLE:"Ski-like protein" OR ABSTRACT:"Ski-like protein" OR TITLE:"SnoN" OR ABSTRACT:"SnoN" OR TITLE:"SnoA" OR ABSTRACT:"SnoA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SKIL, not a curated reading list.