SLC12A2
SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
Overview
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Temozolomide and Antisecretory Factor-enriched Egg Yolk Powder Supplement.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
- 1 · What it is
SLC12A2 (Solute carrier family 12 member 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Glioma & glioblastoma.
- 2 · What goes wrong in cancer
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume.
- 3 · How drugs use it
No product in this corpus aims at SLC12A2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10911 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55011 (protein name, function text, keywords and locations (REST API)); CIViC gene SLC12A2 (2 evidence items, 0 assertions, 1 variants; diseases: Glioblastoma (GraphQL API, CC0))
Biology
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. Location: Basolateral cell membrane (UniProt). Locus 5q23.3 (HGNC).
- Glioma & glioblastoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC12A2" OR ABSTRACT:"SLC12A2" OR TITLE:"solute carrier family 12 member 2" OR ABSTRACT:"solute carrier family 12 member 2" OR TITLE:"Solute carrier family 12 member 2" OR ABSTRACT:"Solute carrier family 12 member 2" OR TITLE:"NKCC1" OR ABSTRACT:"NKCC1" OR TITLE:"BSC2" OR ABSTRACT:"BSC2" OR TITLE:"BSC-2" OR ABSTRACT:"BSC-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC12A2, not a curated reading list.