SLC67A1
SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes genetic literature 0.38, affected pathway 0.76, literature 0.89, genetic association 0.09, somatic mutation 0.71, animal model 0.35).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SLC67A1 (Solute carrier family 67 member A1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
- 3 · How drugs use it
No product in this corpus aims at SLC67A1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:10964 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96BI1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000110628 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Biology
May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. Plays a role in the regulation of lipid metabolism. Location: Apical cell membrane (UniProt). Locus 11p15.4 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SLC67A1" OR ABSTRACT:"SLC67A1" OR TITLE:"solute carrier family 67 member 1" OR ABSTRACT:"solute carrier family 67 member 1" OR TITLE:"Solute carrier family 67 member A1" OR ABSTRACT:"Solute carrier family 67 member A1" OR TITLE:"BWR1A" OR ABSTRACT:"BWR1A" OR TITLE:"TSSC5" OR ABSTRACT:"TSSC5" OR TITLE:"IMPT1" OR ABSTRACT:"IMPT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC67A1, not a curated reading list.