SMAD7
SMAD7 (SMAD family member 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.77).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SMAD7 (SMAD family member 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
SMAD7 (SMAD family member 7) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access.
- 3 · How drugs use it
No product in this corpus aims at SMAD7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:6773 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15105 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101665 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: colorectal cancer 0.58 (GraphQL API, CC0))
Biology
Antagonist of signalling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signalling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Location: Nucleus; Cytoplasm (UniProt). Locus 18q21.1 (HGNC).
- Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SMAD7" OR ABSTRACT:"SMAD7" OR TITLE:"SMAD family member 7" OR ABSTRACT:"SMAD family member 7" OR TITLE:"MADH8" OR ABSTRACT:"MADH8" OR TITLE:"MADH7" OR ABSTRACT:"MADH7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SMAD7, not a curated reading list.