SORCS3
SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.63).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SORCS3 (VPS10 domain-containing receptor SorCS3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density.
- 3 · How drugs use it
No product in this corpus aims at SORCS3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16699 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UPU3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156395 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localisation ofAMPA-type glutamate receptors in the postsynaptic density. Location: Cell membrane; Synaptic cell membrane; Postsynaptic density (UniProt). Locus 10q25.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SORCS3" OR ABSTRACT:"SORCS3" OR TITLE:"sortilin related VPS10 domain containing receptor 3" OR ABSTRACT:"sortilin related VPS10 domain containing receptor 3" OR TITLE:"VPS10 domain-containing receptor SorCS3" OR ABSTRACT:"VPS10 domain-containing receptor SorCS3" OR TITLE:"KIAA1059" OR ABSTRACT:"KIAA1059" OR TITLE:"SORCS" OR ABSTRACT:"SORCS") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SORCS3, not a curated reading list.