SPTBN1
SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.95, animal model 0.51, genetic association 0.28).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
SPTBN1 (Spectrin beta chain, non-erythrocytic 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
- 3 · How drugs use it
No product in this corpus aims at SPTBN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11275 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q01082 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000115306 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Location: Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, M line; Cytoplasm, cytosol; Cell membrane (UniProt). Locus 2p16.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SPTBN1" OR ABSTRACT:"SPTBN1" OR TITLE:"spectrin beta, non-erythrocytic 1" OR ABSTRACT:"spectrin beta, non-erythrocytic 1" OR TITLE:"Spectrin beta chain, non-erythrocytic 1" OR ABSTRACT:"Spectrin beta chain, non-erythrocytic 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SPTBN1, not a curated reading list.