STMN1
STMN1 (Stathmin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer.
Overview
Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · STMN1 (Stathmin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer.
- 1 · What it is
STMN1 (Stathmin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer.
- 2 · What goes wrong in cancer
Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules.
- 3 · How drugs use it
No product in this corpus aims at STMN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:6510 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16949 (protein name, function text, keywords and locations (REST API)); CIViC gene STMN1 (1 evidence items, 0 assertions, 1 variants; diseases: Endometrial Carcinoma (GraphQL API, CC0))
Biology
Involved in the regulation of the microtubule (MT) filament system by destabilising microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. Location: Cytoplasm, cytoskeleton (UniProt). Locus 1p36.11 (HGNC).
- Endometrial cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"STMN1" OR ABSTRACT:"STMN1" OR TITLE:"stathmin 1" OR ABSTRACT:"stathmin 1" OR TITLE:"Stathmin" OR ABSTRACT:"Stathmin" OR TITLE:"OP18" OR ABSTRACT:"OP18" OR TITLE:"PR22" OR ABSTRACT:"PR22" OR TITLE:"PP19" OR ABSTRACT:"PP19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STMN1, not a curated reading list.