TGFA
TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
Overview
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.76, animal model 0.69, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
- 1 · What it is
TGFA (Protransforming growth factor alpha) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
- 2 · What goes wrong in cancer
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
- 3 · How drugs use it
No product in this corpus aims at TGFA yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11765 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01135 (protein name, function text, keywords and locations (REST API)); CIViC gene TGFA (1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000163235 (association with cancer (MONDO_0004992) 0.50; (GraphQL API, CC0))
Biology
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 2p13.3 (HGNC).
- Head and neck squamous cell carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TGFA" OR ABSTRACT:"TGFA" OR TITLE:"transforming growth factor alpha" OR ABSTRACT:"transforming growth factor alpha" OR TITLE:"Protransforming growth factor alpha" OR ABSTRACT:"Protransforming growth factor alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TGFA, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetHGF
Shares Renal cell carcinoma (KEGG map), CIViC, Open Targets Platform.
- TargetVHL
Shares Renal cell carcinoma (KEGG map), CIViC, Open Targets Platform.