TLN1
TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TLN1 (Talin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane.
- 3 · How drugs use it
No product in this corpus aims at TLN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11845 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y490 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137076 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Biology
High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organise the assembly of cortical microtubule stabilising complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims. Location: Cell projection, ruffle membrane; Cytoplasm, cytoskeleton; Cell surface; Cell junction, focal adhesion (UniProt). Locus 9p13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TLN1" OR ABSTRACT:"TLN1" OR TITLE:"talin 1" OR ABSTRACT:"talin 1" OR TITLE:"Talin-1" OR ABSTRACT:"Talin-1" OR TITLE:"ILWEQ" OR ABSTRACT:"ILWEQ") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLN1, not a curated reading list.