TLX1
TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Overview
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.84, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 1 · What it is
TLX1 (T-cell leukaemia homeobox protein 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
- 3 · How drugs use it
No product in this corpus aims at TLX1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:5056 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31314 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107807 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Biology
Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Location: Nucleus (UniProt). Locus 10q24.31 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TLX1" OR ABSTRACT:"TLX1" OR TITLE:"T cell leukemia homeobox 1" OR ABSTRACT:"T cell leukemia homeobox 1" OR TITLE:"T-cell leukemia homeobox protein 1" OR ABSTRACT:"T-cell leukemia homeobox protein 1" OR TITLE:"TCL3" OR ABSTRACT:"TCL3" OR TITLE:"HOX11" OR ABSTRACT:"HOX11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TLX1, not a curated reading list.