TMEM127
TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
Overview
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.79, literature 0.19, genetic association 0.59, somatic mutation 0.93, animal model 0.47).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
- 1 · What it is
TMEM127 (Transmembrane protein 127) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours and Melanoma.
- 2 · What goes wrong in cancer
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor.
- 3 · How drugs use it
No product in this corpus aims at TMEM127 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:26038 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75204 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000135956 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: melanoma 0.51, neuroendocrine neoplasm 0.78 (GraphQL API, CC0))
Biology
Controls cell proliferation acting as a negative regulator of TOR signalling pathway mediated by mTORC1. May act as a tumour suppressor. Location: Cell membrane; Cytoplasm (UniProt). Locus 2q11.2 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.78 with neuroendocrine neoplasm (MONDO_0019496)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TMEM127" OR ABSTRACT:"TMEM127" OR TITLE:"transmembrane protein 127" OR ABSTRACT:"transmembrane protein 127" OR TITLE:"Transmembrane protein 127" OR ABSTRACT:"Transmembrane protein 127" OR TITLE:"FLJ20507" OR ABSTRACT:"FLJ20507" OR TITLE:"FLJ22257" OR ABSTRACT:"FLJ22257") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM127, not a curated reading list.