TMEM238L
TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.90, genetic association 0.67).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
TMEM238L (Transmembrane protein 238-like) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt).
- 3 · How drugs use it
No product in this corpus aims at TMEM238L yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:44356 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt A6NJY4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000263429 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.53 (GraphQL API, CC0))
Biology
May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity. Location: Endoplasmic reticulum membrane (UniProt). Locus 17p13.1-p12 (HGNC).
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TMEM238L" OR ABSTRACT:"TMEM238L" OR TITLE:"transmembrane protein 238 like" OR ABSTRACT:"transmembrane protein 238 like" OR TITLE:"Transmembrane protein 238-like" OR ABSTRACT:"Transmembrane protein 238-like" OR TITLE:"FORCP" OR ABSTRACT:"FORCP" OR TITLE:"LINC00675" OR ABSTRACT:"LINC00675") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TMEM238L, not a curated reading list.