TNFRSF13B
TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
Overview
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.93, animal model 0.48, genetic association 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
- 1 · What it is
TNFRSF13B (Tumour necrosis factor receptor superfamily member 13B) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Multiple myeloma.
- 2 · What goes wrong in cancer
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1.
- 3 · How drugs use it
No product in this corpus aims at TNFRSF13B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:18153 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14836 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000240505 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: plasma cell myeloma 0.56 (GraphQL API, CC0))
Biology
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Location: Membrane (UniProt). Locus 17p11.2 (HGNC).
- Multiple myeloma: Open Targets association 0.56 with plasma cell myeloma (MONDO_0009693)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TNFRSF13B" OR ABSTRACT:"TNFRSF13B" OR TITLE:"TNF receptor superfamily member 13B" OR ABSTRACT:"TNF receptor superfamily member 13B" OR TITLE:"Tumor necrosis factor receptor superfamily member 13B" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 13B" OR TITLE:"CD267" OR ABSTRACT:"CD267" OR TITLE:"IGAD2" OR ABSTRACT:"IGAD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFRSF13B, not a curated reading list.