TNS1
TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Overview
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.91, animal model 0.39, genetic association 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TNS1 (Tensin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation.
- 3 · How drugs use it
No product in this corpus aims at TNS1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:11973 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HBL0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000079308 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Biology
May act as a protein phosphatase and/or a lipid phosphatase. Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarisation and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. Location: Cell surface; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 2q35 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TNS1" OR ABSTRACT:"TNS1" OR TITLE:"tensin 1" OR ABSTRACT:"tensin 1" OR TITLE:"Tensin-1" OR ABSTRACT:"Tensin-1" OR TITLE:"DKFZp586K0617" OR ABSTRACT:"DKFZp586K0617" OR TITLE:"PPP1R155" OR ABSTRACT:"PPP1R155" OR TITLE:"MXRA6" OR ABSTRACT:"MXRA6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNS1, not a curated reading list.