TPH2
TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
Overview
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
- 1 · What it is
TPH2 (Tryptophan 5-hydroxylase 2) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Neuroendocrine tumours.
- 2 · What goes wrong in cancer
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates.
- 3 · How drugs use it
No product in this corpus aims at TPH2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:20692 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IWU9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000139287 (per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.53 (GraphQL API, CC0))
Biology
Neuron-specific enzyme that catalyses the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates. Plays a crucial role in regulating mood, anxiety and sleep. Locus 12q21.1 (HGNC).
- Neuroendocrine tumours: Open Targets association 0.53 with neuroendocrine neoplasm (MONDO_0019496)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TPH2" OR ABSTRACT:"TPH2" OR TITLE:"tryptophan hydroxylase 2" OR ABSTRACT:"tryptophan hydroxylase 2" OR TITLE:"Tryptophan 5-hydroxylase 2" OR ABSTRACT:"Tryptophan 5-hydroxylase 2" OR TITLE:"FLJ37295" OR ABSTRACT:"FLJ37295") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TPH2, not a curated reading list.